View source for Dr. P. Shing Ho Laboratory

== Research topics ==
* [[Z-DNA]]
* [[Z-Hunt|ZHunt Online Server]]
* Topoisomerase
* DNA topology
* DNA supercoil
* Linking number
* DNA Gyrase &mdash; adds negative supercoils to DNA using ATP hydrolysis for energy (9 kcal/mole). 200bp of DNA wrap around the gyrase holoenzyme molecule, ATP is bound, and each strand is cut (staggered cuts) and covalently linked to different tyrosines to "anchor" the DNA.
** DNA gyrase inhibitors:
:: - nalidixic acid (prevents strand cutting and rejoining); and
:: - novobiocin (blocks ATP binding)
* CCAAT-Enhancer-Binding Proteins
* Macrophage Colony-Stimulating Factor
* Möbius strip