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		<id>http://wiki.christophchamp.com/index.php?action=history&amp;feed=atom&amp;title=Metropolis-coupled_Markov_chain_Monte_Carlo</id>
		<title>Metropolis-coupled Markov chain Monte Carlo - Revision history</title>
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		<updated>2026-04-30T06:55:20Z</updated>
		<subtitle>Revision history for this page on the wiki</subtitle>
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	<entry>
		<id>http://wiki.christophchamp.com/index.php?title=Metropolis-coupled_Markov_chain_Monte_Carlo&amp;diff=1547&amp;oldid=prev</id>
		<title>Christoph: Added more info. + &quot;References&quot;</title>
		<link rel="alternate" type="text/html" href="http://wiki.christophchamp.com/index.php?title=Metropolis-coupled_Markov_chain_Monte_Carlo&amp;diff=1547&amp;oldid=prev"/>
				<updated>2005-12-30T00:37:33Z</updated>
		
		<summary type="html">&lt;p&gt;Added more info. + &amp;quot;References&amp;quot;&lt;/p&gt;
&lt;table class='diff diff-contentalign-left'&gt;
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				&lt;td colspan='2' style=&quot;background-color: white; color:black; text-align: center;&quot;&gt;← Older revision&lt;/td&gt;
				&lt;td colspan='2' style=&quot;background-color: white; color:black; text-align: center;&quot;&gt;Revision as of 00:37, 30 December 2005&lt;/td&gt;
				&lt;/tr&gt;&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l1&quot; &gt;Line 1:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 1:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class='diff-marker'&gt;−&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #ffe49c; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;'''Metropolis-coupled Markov chain Monte Carlo''' (or '''MCMCMC''' or '''(MC)&amp;lt;sup&amp;gt;3&amp;lt;/sup&amp;gt;''') is a variant of [[Markov chain Monte Carlo]] in which multiple chains are run in parallel, each with a different &amp;quot;temperature&amp;quot;. Only the information from the cold chain is recorded. Periodically, trees between chains may be swapped.&lt;/div&gt;&lt;/td&gt;&lt;td class='diff-marker'&gt;+&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;'''Metropolis-coupled Markov chain Monte Carlo''' (or '''MCMCMC''' or '''(MC)&amp;lt;sup&amp;gt;3&amp;lt;/sup&amp;gt;''') is a variant of [[Markov chain Monte Carlo]] in which multiple chains are run in parallel, each with a different &amp;quot;temperature&amp;quot; &lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;(Geyer, 1991)&lt;/ins&gt;. Only the information from the cold chain is recorded. Periodically, trees between chains may be swapped.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot;&gt;&amp;#160;&lt;/td&gt;&lt;td class='diff-marker'&gt;+&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&amp;#160;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot;&gt;&amp;#160;&lt;/td&gt;&lt;td class='diff-marker'&gt;+&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;&amp;lt;blockquote&amp;gt;&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot;&gt;&amp;#160;&lt;/td&gt;&lt;td class='diff-marker'&gt;+&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;&amp;quot;Some of these chains are '[[Heated chains|heated]]' by raising the [[posterior probability]] to a power &amp;amp;beta;. For example, if ''f'' (&amp;amp;psi;|'''''X''''') is the posterior probability density distribution of the phylogenetic parameters, then a heated version of the posterior distribution is ''f'' (&amp;amp;psi;|'''''X''''')&amp;lt;sup&amp;gt;&amp;amp;beta;&amp;lt;/sup&amp;gt;. Here, &amp;amp;beta;(0 &amp;lt; &amp;amp;beta; &amp;lt; 1) is the heat value of the chain. Heating a Markov chain increases the acceptance probability of new states. A heated chain tends to accept more states than a cold chain, allowing a heated chain to more readily cross valleys in the landscapes of trees.&amp;quot; (Altekar ''et al.'', 2004).&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot;&gt;&amp;#160;&lt;/td&gt;&lt;td class='diff-marker'&gt;+&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins class=&quot;diffchange diffchange-inline&quot;&gt;&amp;lt;/blockquote&amp;gt;&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class='diff-marker'&gt;&amp;#160;&lt;/td&gt;&lt;td style=&quot;background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;/td&gt;&lt;td class='diff-marker'&gt;&amp;#160;&lt;/td&gt;&lt;td style=&quot;background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class='diff-marker'&gt;&amp;#160;&lt;/td&gt;&lt;td style=&quot;background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;(MC)&amp;lt;sup&amp;gt;3&amp;lt;/sup&amp;gt; can be used to empirically determine the posterior probability distribution of trees, branch lengths, and substitution parameters.&lt;/div&gt;&lt;/td&gt;&lt;td class='diff-marker'&gt;&amp;#160;&lt;/td&gt;&lt;td style=&quot;background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;(MC)&amp;lt;sup&amp;gt;3&amp;lt;/sup&amp;gt; can be used to empirically determine the posterior probability distribution of trees, branch lengths, and substitution parameters.&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot; id=&quot;mw-diff-left-l24&quot; &gt;Line 24:&lt;/td&gt;
&lt;td colspan=&quot;2&quot; class=&quot;diff-lineno&quot;&gt;Line 28:&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class='diff-marker'&gt;&amp;#160;&lt;/td&gt;&lt;td style=&quot;background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;* [[Metropolis-Hastings]]&lt;/div&gt;&lt;/td&gt;&lt;td class='diff-marker'&gt;&amp;#160;&lt;/td&gt;&lt;td style=&quot;background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;* [[Metropolis-Hastings]]&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class='diff-marker'&gt;&amp;#160;&lt;/td&gt;&lt;td style=&quot;background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;* [[Heated chains]]&lt;/div&gt;&lt;/td&gt;&lt;td class='diff-marker'&gt;&amp;#160;&lt;/td&gt;&lt;td style=&quot;background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;* [[Heated chains]]&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot;&gt;&amp;#160;&lt;/td&gt;&lt;td class='diff-marker'&gt;+&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot;&gt;&amp;#160;&lt;/td&gt;&lt;td class='diff-marker'&gt;+&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;== References ==&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot;&gt;&amp;#160;&lt;/td&gt;&lt;td class='diff-marker'&gt;+&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;* Altekar G, Dwarkadas S, Huelsenbeck JP, and Ronquist F (2004). Parallel Metropolis coupled Markov chain Monte Carlo for Bayesian phylogenetic inference. ''Bioinformatics''.&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td colspan=&quot;2&quot;&gt;&amp;#160;&lt;/td&gt;&lt;td class='diff-marker'&gt;+&lt;/td&gt;&lt;td style=&quot;color:black; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #a3d3ff; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;&lt;ins style=&quot;font-weight: bold; text-decoration: none;&quot;&gt;* Geyer CJ (1991). Markov chain Monte Carlo maximum likelihood. In Keramidas (ed.), ''Computing Science and Statistics: Proceedings of the 23rd Symposium on the Interface''. Fairfax Station: Interface Foundation, pp. 156-163.&lt;/ins&gt;&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class='diff-marker'&gt;&amp;#160;&lt;/td&gt;&lt;td style=&quot;background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;/td&gt;&lt;td class='diff-marker'&gt;&amp;#160;&lt;/td&gt;&lt;td style=&quot;background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class='diff-marker'&gt;&amp;#160;&lt;/td&gt;&lt;td style=&quot;background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Category:Academic Research]]&lt;/div&gt;&lt;/td&gt;&lt;td class='diff-marker'&gt;&amp;#160;&lt;/td&gt;&lt;td style=&quot;background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Category:Academic Research]]&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;tr&gt;&lt;td class='diff-marker'&gt;&amp;#160;&lt;/td&gt;&lt;td style=&quot;background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Category:Statistics]]&lt;/div&gt;&lt;/td&gt;&lt;td class='diff-marker'&gt;&amp;#160;&lt;/td&gt;&lt;td style=&quot;background-color: #f9f9f9; color: #333333; font-size: 88%; border-style: solid; border-width: 1px 1px 1px 4px; border-radius: 0.33em; border-color: #e6e6e6; vertical-align: top; white-space: pre-wrap;&quot;&gt;&lt;div&gt;[[Category:Statistics]]&lt;/div&gt;&lt;/td&gt;&lt;/tr&gt;
&lt;/table&gt;</summary>
		<author><name>Christoph</name></author>	</entry>

	<entry>
		<id>http://wiki.christophchamp.com/index.php?title=Metropolis-coupled_Markov_chain_Monte_Carlo&amp;diff=1543&amp;oldid=prev</id>
		<title>Christoph: Started article</title>
		<link rel="alternate" type="text/html" href="http://wiki.christophchamp.com/index.php?title=Metropolis-coupled_Markov_chain_Monte_Carlo&amp;diff=1543&amp;oldid=prev"/>
				<updated>2005-12-30T00:05:53Z</updated>
		
		<summary type="html">&lt;p&gt;Started article&lt;/p&gt;
&lt;p&gt;&lt;b&gt;New page&lt;/b&gt;&lt;/p&gt;&lt;div&gt;'''Metropolis-coupled Markov chain Monte Carlo''' (or '''MCMCMC''' or '''(MC)&amp;lt;sup&amp;gt;3&amp;lt;/sup&amp;gt;''') is a variant of [[Markov chain Monte Carlo]] in which multiple chains are run in parallel, each with a different &amp;quot;temperature&amp;quot;. Only the information from the cold chain is recorded. Periodically, trees between chains may be swapped.&lt;br /&gt;
&lt;br /&gt;
(MC)&amp;lt;sup&amp;gt;3&amp;lt;/sup&amp;gt; can be used to empirically determine the posterior probability distribution of trees, branch lengths, and substitution parameters.&lt;br /&gt;
&lt;br /&gt;
&lt;br /&gt;
; Temperature : A variable used in Metropolis-coupled Markov chain Monte Carlo. The temperature affects the likelihood of acceptance of a proposed tree and also affects the likelihood that two chains will accept a proposed tree swap.&lt;br /&gt;
&lt;br /&gt;
== Practice ==&lt;br /&gt;
* Only one chain is sampled&lt;br /&gt;
* The other chains are heated (i.e. they can take bigger steps)&lt;br /&gt;
* Chains can swap states&lt;br /&gt;
* Allows crossing of valleys&lt;br /&gt;
* This process of linking heated chains is called &amp;quot;Metropolis-coupling&amp;quot;&lt;br /&gt;
* The full-fledged Bayesian analysis is MCMCMC!&lt;br /&gt;
* The heated chains use powers of the likelihood ratio in their acceptance ratio&lt;br /&gt;
* We must '''only''' use the main chain to calculate posterior probabilities.&lt;br /&gt;
* In reality, all these factors involve very large numbers. It's not uncommon to throw away thousands of trees as part of the burn-in and calculate the posterior from millions of trees.&lt;br /&gt;
* Heated chains: usually 4-5.&lt;br /&gt;
* [[MrBayes]] by Huelsenbeck is the main program in current use&lt;br /&gt;
&lt;br /&gt;
== See also ==&lt;br /&gt;
* [[Markov chain]]&lt;br /&gt;
* [[Markov chain Monte Carlo]]&lt;br /&gt;
* [[Metropolis-Hastings]]&lt;br /&gt;
* [[Heated chains]]&lt;br /&gt;
&lt;br /&gt;
[[Category:Academic Research]]&lt;br /&gt;
[[Category:Statistics]]&lt;/div&gt;</summary>
		<author><name>Christoph</name></author>	</entry>

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