Difference between revisions of "Dr. Ethan A. Merritt Laboratory"
From Christoph's Personal Wiki
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The '''Dr. Ethan A. Merritt Laboratory''' <!-- is where I did [[:Category:Academic Research|scientific research]] from September 2006 - present. --> | The '''Dr. Ethan A. Merritt Laboratory''' <!-- is where I did [[:Category:Academic Research|scientific research]] from September 2006 - present. --> | ||
| − | == Research topics == | + | ==Research topics== |
| − | * structure-based drug design | + | *structure-based drug design |
| − | * high-resolution protein crystallography | + | *high-resolution protein crystallography |
| − | == References == | + | ==MSGPP== |
| + | I am part of the Medical Structural Genomics of Pathogenic Protozoa Consortium (MSGPP). The pathogenic protozoa we study include the following: | ||
| + | ===[[wikipedia:Trypanosoma|Trypanosoma]]=== | ||
| + | ;''[[wikipedia:Trypanosoma cruzi|Trypanosoma cruzi]]'' : Chagas' Disease | ||
| + | ;''[[wikipedia:Trypanosoma brucei|Trypanosoma brucei]]'' : Sleeping Sickness | ||
| + | ;''[[wikipedia:Leishmania|Leishmania spp.]]'' : Leishmaniasis | ||
| + | ===[[wikipedia:Apicomplexa|Apicomplexa]]=== | ||
| + | ;''[[wikipedia:Plasmodium falciparum|Plasmodium falciparum]]'' : Malaria | ||
| + | ;''[[wikipedia:Plasmodium vivax|Plasmodium vivax]]'' : Malaria | ||
| + | ;''[[wikipedia:Toxoplasma gondii|Toxoplasma gondii]]'' : Toxoplasmosis | ||
| + | ===Others=== | ||
| + | ;''[[wikipedia:Entamoeba histolytica|Entamoeba histolytica]]'' : Amoebiasis | ||
| + | ;''[[wikipedia:Giardia lamblia|Giardia lamblia]]'' : Giardiasis | ||
| + | ;''[[wikipedia:Cryptosporidium parvum|Cryptosporidium parvum]]'' : Cryptosporidiosis | ||
| + | |||
| + | ==References== | ||
<references/> | <references/> | ||
| − | === Further reading === | + | ===Further reading=== |
| − | * Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and ''E. coli'' heat-labile enterotoxin. ''JACS, 124:8818-8824''. | + | *Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and ''E. coli'' heat-labile enterotoxin. ''JACS, 124:8818-8824''. |
| − | * Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. ''Current Opinion in Structural Biology, 10:680-686''. | + | *Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. ''Current Opinion in Structural Biology, 10:680-686''. |
| − | * Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. ''Acta Cryst, D55:1997-2004''. | + | *Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. ''Acta Cryst, D55:1997-2004''. |
| − | * Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. ''Acta Cryst, D55:1109-1117''. | + | *Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. ''Acta Cryst, D55:1109-1117''. |
==See also== | ==See also== | ||
| Line 17: | Line 32: | ||
*[[Python Macromolecular Library]] (mmLib) | *[[Python Macromolecular Library]] (mmLib) | ||
| − | == External links == | + | ==External links== |
| − | * [http://www.bmsc.washington.edu/people/merritt/ Dr. Ethan A. Merritt Laboratory website] | + | *[http://www.bmsc.washington.edu/people/merritt/ Dr. Ethan A. Merritt Laboratory website] |
| − | * [http://skuld.bmsc.washington.edu/~tlsmd/ TLSMD Server] | + | *[http://skuld.bmsc.washington.edu/~tlsmd/ TLSMD Server] |
| − | * [http://www.sgpp.org/ Structural Genomics of Pathogenic Protozoa] | + | *[http://www.sgpp.org/ Structural Genomics of Pathogenic Protozoa] |
[[Category:Academic Research]] | [[Category:Academic Research]] | ||
Revision as of 01:02, 1 August 2007
The Dr. Ethan A. Merritt Laboratory
Contents
Research topics
- structure-based drug design
- high-resolution protein crystallography
MSGPP
I am part of the Medical Structural Genomics of Pathogenic Protozoa Consortium (MSGPP). The pathogenic protozoa we study include the following:
Trypanosoma
- Trypanosoma cruzi
- Chagas' Disease
- Trypanosoma brucei
- Sleeping Sickness
- Leishmania spp.
- Leishmaniasis
Apicomplexa
- Plasmodium falciparum
- Malaria
- Plasmodium vivax
- Malaria
- Toxoplasma gondii
- Toxoplasmosis
Others
- Entamoeba histolytica
- Amoebiasis
- Giardia lamblia
- Giardiasis
- Cryptosporidium parvum
- Cryptosporidiosis
References
Further reading
- Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin. JACS, 124:8818-8824.
- Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. Current Opinion in Structural Biology, 10:680-686.
- Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. Acta Cryst, D55:1997-2004.
- Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. Acta Cryst, D55:1109-1117.
See also
- TLSMD
- Python Macromolecular Library (mmLib)
