Dr. Ethan A. Merritt Laboratory
From Christoph's Personal Wiki
The Dr. Ethan A. Merritt Laboratory is where I did scientific research, scientific programming, and worked as a Linux System Administrator from October 2006 to October 2010.
Contents
Research topics
- TLSMD (Translation, Libration, Screw Molecular Dynamics)
- structure-based drug design
- high-resolution protein crystallography
Peer-reviewed papers published
- Frank Zucker, P. Christoph Champ, and Ethan A. Merritt (2010). "Validation of crystallographic models containing TLS or other descriptions of anisotropy". Acta Cryst., D66:889-900.
MSGPP
I was part of the Medical Structural Genomics of Pathogenic Protozoa Consortium (MSGPP). The pathogenic protozoa we studied included the following:
Trypanosoma
- Trypanosoma cruzi
- Chagas' Disease (aka American Trypanosomiasis)
- Trypanosoma brucei
- Sleeping Sickness (aka African Trypanosomiasis)
- Leishmania spp.
- Leishmaniasis
Apicomplexa
- Plasmodium falciparum
- Malaria
- Plasmodium vivax
- Malaria
- Toxoplasma gondii
- Toxoplasmosis
Others
- Entamoeba histolytica
- Amoebiasis
- Giardia lamblia
- Giardiasis
- Cryptosporidium parvum
- Cryptosporidiosis
References
Further reading
- Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin. JACS, 124:8818-8824.
- Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. Current Opinion in Structural Biology, 10:680-686.
- Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. Acta Cryst, D55:1997-2004.
- Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. Acta Cryst, D55:1109-1117.
See also
- TLSMD
- Python Macromolecular Library (mmLib)
