Swiss-Prot
Swiss-Prot is a manually curated biological database of protein sequences started by Amos Bairoch and developed by the Swiss Institute of Bioinformatics and the European Bioinformatics Institute.[1]
Swiss-Prot strives to provide reliable protein sequences associated with a high level of annotation, including each of the following: *the description of the function of a protein;
- its domains structure;
- post-translational modifications;
- variants;
- a minimal level of redundancy;
- a high level of integration with other databases;
- etc.
Swiss-Prot and its automatically curated supplement TrEMBL, have joined with the Protein Information Resource protein database to produce the UniProt Knowledgebase, the world's most comprehensive catalogue of information on proteins. As of 3 April 2007, UniProtKB/Swiss-Prot release 52.2 contains 263,525 entries. As of 3 April 2007, the UniProtKB/TrEMBL release 35.2 contains 4,232,122 entries.
The UniProt consortium produced 3 database components, each optimised for different uses:
- The UniProt Knowledgebase (UniProtKB (Swiss-Prot + TrEMBL));
- The UniProt Non-redundant Reference (UniRef) databases, which combine closely related sequences into a single record to speed similarity searches; and
- The UniProt Archive (UniParc), which is a comprehensive repository of protein sequences, reflecting the history of all protein sequences.
References
- ↑ Bairoch A (2000). "Serendipity in bioinformatics, the tribulations of a Swiss bioinformatician through exciting times!" Bioinformatics, 16:48-64
External links
- Swiss-Prot Protein Database (Swiss Institute of Bioinformatics)
- UniProt (Swiss Institute of Bioinformatics)
- Definition of Swiss-Prot format files
