Critical Assessment of PRotein Interactions

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Critical Assessment of PRotein Interactions (or CAPRI) is a community wide experiment on the comparative evaluation of protein-protein docking for structure prediction. It is hosted by the EMBL/EBI-MSD Group several times each year.

The Critical Assessment of Predicted Interactions (CAPRI)[1] is an ongoing series of events in which researchers throughout the community try to dock the same proteins, as provided by the assessors. Rounds take place approximately every 6 months. Each round contains between one and six target protein-protein complexes whose structures have been recently determined experimentally. The coordinates and are held privately by the assessors, with the cooperation of the structural biologists who determined them. The assessment of submissions is double blind.

CAPRI attracts a high level of participation (37 groups participated worldwide in round seven) and a high level of interest from the biological community in general. Although CAPRI results are of little statistical significance owing to the small number of targets in each round, the rôle of CAPRI in stimulating discourse is significant. (The CASP assessment is a similar exercise in the field of protein structure prediction).

My involvement

I was a participant of "Round 6" (17-Jan-2005) and "Round 7" (29-May-2005) of these experiments or events. Our group presented the "SmoothDock Server".

See also


  1. Proteins: Structure, Function, and Genetics (special edition) Volume 52, Issue 1, 2003, all pages.

Further reading

  • CAPRI: A Critical Assessment of PRedicted Interactions Collection of Articles on Capri results published in a Special Issue of Proteins: Structure, Function, and Genetics, 52(1):1-122 (2003).
  • Janin J (2002). Welcome to CAPRI: A Critical Assessment of PRedicted Interactions. Proteins: Structure, Function, and Genetics, 47(3):257.
  • Vajda S, Vakser IA, Sternberg MJE, and Janin J (2002). Meeting Report. Modeling of protein interactions in genomes. Proteins: Structure, Function, and Genetics, 47(4):444-446.

External links