Difference between revisions of "Dr. Ethan A. Merritt Laboratory"
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I am part of the Medical Structural Genomics of Pathogenic Protozoa Consortium (MSGPP). The pathogenic protozoa we study include the following: | I am part of the Medical Structural Genomics of Pathogenic Protozoa Consortium (MSGPP). The pathogenic protozoa we study include the following: | ||
===[[wikipedia:Trypanosoma|Trypanosoma]]=== | ===[[wikipedia:Trypanosoma|Trypanosoma]]=== | ||
| − | ;''[[wikipedia:Trypanosoma cruzi|Trypanosoma cruzi]]'' : Chagas' Disease | + | ;''[[wikipedia:Trypanosoma cruzi|Trypanosoma cruzi]]'' : Chagas' Disease (aka American Trypanosomiasis) |
| − | ;''[[wikipedia:Trypanosoma brucei|Trypanosoma brucei]]'' : Sleeping Sickness | + | ;''[[wikipedia:Trypanosoma brucei|Trypanosoma brucei]]'' : Sleeping Sickness (aka African Trypanosomiasis) |
;''[[wikipedia:Leishmania|Leishmania spp.]]'' : Leishmaniasis | ;''[[wikipedia:Leishmania|Leishmania spp.]]'' : Leishmaniasis | ||
===[[wikipedia:Apicomplexa|Apicomplexa]]=== | ===[[wikipedia:Apicomplexa|Apicomplexa]]=== | ||
Revision as of 23:48, 20 August 2007
The Dr. Ethan A. Merritt Laboratory
Contents
Research topics
- structure-based drug design
- high-resolution protein crystallography
MSGPP
I am part of the Medical Structural Genomics of Pathogenic Protozoa Consortium (MSGPP). The pathogenic protozoa we study include the following:
Trypanosoma
- Trypanosoma cruzi
- Chagas' Disease (aka American Trypanosomiasis)
- Trypanosoma brucei
- Sleeping Sickness (aka African Trypanosomiasis)
- Leishmania spp.
- Leishmaniasis
Apicomplexa
- Plasmodium falciparum
- Malaria
- Plasmodium vivax
- Malaria
- Toxoplasma gondii
- Toxoplasmosis
Others
- Entamoeba histolytica
- Amoebiasis
- Giardia lamblia
- Giardiasis
- Cryptosporidium parvum
- Cryptosporidiosis
References
Further reading
- Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin. JACS, 124:8818-8824.
- Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. Current Opinion in Structural Biology, 10:680-686.
- Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. Acta Cryst, D55:1997-2004.
- Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. Acta Cryst, D55:1109-1117.
See also
- TLSMD
- Python Macromolecular Library (mmLib)
