Difference between revisions of "Dr. Ethan A. Merritt Laboratory"

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The '''Dr. Ethan A. Merritt Laboratory''' <!-- is where I did [[:Category:Academic Research|scientific research]] from September 2006 - present. -->
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The '''Dr. Ethan A. Merritt Laboratory''' is where I did [[:Category:Academic Research|scientific research]], scientific programming, and worked as a Linux System Administrator from October 2006 to October 2010.
  
== Research topics ==
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==Research topics==
* structure-based drug design
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*[[TLSMD]] (Translation, Libration, Screw Molecular Dynamics)
* high-resolution protein crystallography
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*structure-based drug design
 +
*high-resolution protein crystallography
  
== References ==
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==Peer-reviewed papers published==
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* Frank Zucker, '''P. Christoph Champ''', and Ethan A. Merritt (2010). "[https://docs.google.com/viewer?a=v&pid=explorer&chrome=true&srcid=0B7cFvC52gEb9MTRmNDQyNmYtZDVhNS00OTViLTkxZGItODk3ZmU2ZjdjYzM5&hl=en Validation of crystallographic models containing TLS or other descriptions of anisotropy]". ''Acta Cryst., D66:889-900''.
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==MSGPP==
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I was part of the Medical Structural Genomics of Pathogenic Protozoa Consortium (MSGPP). The pathogenic protozoa we studied included the following:
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===[[wikipedia:Trypanosoma|Trypanosoma]]===
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;''[[wikipedia:Trypanosoma cruzi|Trypanosoma cruzi]]'' : Chagas' Disease (aka American Trypanosomiasis)
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;''[[wikipedia:Trypanosoma brucei|Trypanosoma brucei]]'' : Sleeping Sickness (aka African Trypanosomiasis)
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;''[[wikipedia:Leishmania|Leishmania spp.]]'' : Leishmaniasis
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===[[wikipedia:Apicomplexa|Apicomplexa]]===
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;''[[wikipedia:Plasmodium falciparum|Plasmodium falciparum]]'' : Malaria
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;''[[wikipedia:Plasmodium vivax|Plasmodium vivax]]'' : Malaria
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;''[[wikipedia:Toxoplasma gondii|Toxoplasma gondii]]'' : Toxoplasmosis
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===Others===
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;''[[wikipedia:Entamoeba histolytica|Entamoeba histolytica]]'' : Amoebiasis
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;''[[wikipedia:Giardia lamblia|Giardia lamblia]]'' : Giardiasis
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;''[[wikipedia:Cryptosporidium parvum|Cryptosporidium parvum]]'' : Cryptosporidiosis
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 +
==References==
 
<references/>
 
<references/>
=== Further reading ===
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===Further reading===
* Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and ''E. coli'' heat-labile enterotoxin. ''JACS, 124:8818-8824''.
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*Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and ''E. coli'' heat-labile enterotoxin. ''JACS, 124:8818-8824''.
* Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. ''Current Opinion in Structural Biology, 10:680-686''.
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*Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. ''Current Opinion in Structural Biology, 10:680-686''.
* Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. ''Acta Cryst, D55:1997-2004''.
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*Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. ''Acta Cryst, D55:1997-2004''.
* Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. ''Acta Cryst, D55:1109-1117''.
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*Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. ''Acta Cryst, D55:1109-1117''.
  
 
==See also==
 
==See also==
 
*[[TLSMD]]
 
*[[TLSMD]]
 
*[[Python Macromolecular Library]] (mmLib)
 
*[[Python Macromolecular Library]] (mmLib)
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*''[[Curriculum Vitae]]''
  
== External links ==
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==External links==
* [http://www.bmsc.washington.edu/people/merritt/ Dr. Ethan A. Merritt Laboratory website]
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*[http://www.bmsc.washington.edu/people/merritt/ Dr. Ethan A. Merritt Laboratory website]
* [http://skuld.bmsc.washington.edu/~tlsmd/ TLSMD Server]
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*[http://skuld.bmsc.washington.edu/~tlsmd/ TLSMD Server]
* [http://www.sgpp.org/ Structural Genomics of Pathogenic Protozoa]
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*[http://www.msgpp.org/ Medical Structural Genomics of Pathogenic Protozoa]
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===Genome projects===
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*[http://www.plasmodb.org/ PlasmoDB] &mdash; ''Plasmodium'' spp.
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*[http://www.genedb.org/ GeneDB] &mdash; ''Trypanosomatids, Entamoeba, Plasmodium''
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*[http://tcruzidb.org/ TcruziDB] &mdash; ''T. cruzi''
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*[http://cryptodb.org/ CryptoDB] &mdash; ''Cryptosporidium''
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*[http://gmod.mbl.edu/perl/site/giardia GardiaDB] &mdash; ''Giardia lamblia''
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*[http://www.toxodb.org/ ToxoDB] &mdash; ''Toxoplasma gondii''
  
 
[[Category:Academic Research]]
 
[[Category:Academic Research]]

Latest revision as of 03:36, 27 December 2012

The Dr. Ethan A. Merritt Laboratory is where I did scientific research, scientific programming, and worked as a Linux System Administrator from October 2006 to October 2010.

Research topics

  • TLSMD (Translation, Libration, Screw Molecular Dynamics)
  • structure-based drug design
  • high-resolution protein crystallography

Peer-reviewed papers published

MSGPP

I was part of the Medical Structural Genomics of Pathogenic Protozoa Consortium (MSGPP). The pathogenic protozoa we studied included the following:

Trypanosoma

Trypanosoma cruzi 
Chagas' Disease (aka American Trypanosomiasis)
Trypanosoma brucei 
Sleeping Sickness (aka African Trypanosomiasis)
Leishmania spp. 
Leishmaniasis

Apicomplexa

Plasmodium falciparum 
Malaria
Plasmodium vivax 
Malaria
Toxoplasma gondii 
Toxoplasmosis

Others

Entamoeba histolytica 
Amoebiasis
Giardia lamblia 
Giardiasis
Cryptosporidium parvum 
Cryptosporidiosis

References

Further reading

  • Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin. JACS, 124:8818-8824.
  • Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. Current Opinion in Structural Biology, 10:680-686.
  • Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. Acta Cryst, D55:1997-2004.
  • Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. Acta Cryst, D55:1109-1117.

See also

External links

Genome projects