Difference between revisions of "Dr. Ethan A. Merritt Laboratory"

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(MSGPP)
(Research topics)
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==Research topics==
 
==Research topics==
 +
*[[TLSMD]] (Translation, Libration, Screw Molecular Dynamics)
 
*structure-based drug design
 
*structure-based drug design
 
*high-resolution protein crystallography
 
*high-resolution protein crystallography

Revision as of 00:33, 5 April 2009

The Dr. Ethan A. Merritt Laboratory

Research topics

  • TLSMD (Translation, Libration, Screw Molecular Dynamics)
  • structure-based drug design
  • high-resolution protein crystallography

MSGPP

I am part of the Medical Structural Genomics of Pathogenic Protozoa Consortium (MSGPP). The pathogenic protozoa we study include the following:

Trypanosoma

Trypanosoma cruzi 
Chagas' Disease (aka American Trypanosomiasis)
Trypanosoma brucei 
Sleeping Sickness (aka African Trypanosomiasis)
Leishmania spp. 
Leishmaniasis

Apicomplexa

Plasmodium falciparum 
Malaria
Plasmodium vivax 
Malaria
Toxoplasma gondii 
Toxoplasmosis

Others

Entamoeba histolytica 
Amoebiasis
Giardia lamblia 
Giardiasis
Cryptosporidium parvum 
Cryptosporidiosis

References

Further reading

  • Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin. JACS, 124:8818-8824.
  • Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. Current Opinion in Structural Biology, 10:680-686.
  • Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. Acta Cryst, D55:1997-2004.
  • Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. Acta Cryst, D55:1109-1117.

See also

External links

Genome projects