Difference between revisions of "Dr. Ethan A. Merritt Laboratory"

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The '''Dr. Ethan A. Merritt Laboratory''' <!-- is where I did [[:Category:Academic Research|scientific research]] from September 2006 - present. -->
 
The '''Dr. Ethan A. Merritt Laboratory''' <!-- is where I did [[:Category:Academic Research|scientific research]] from September 2006 - present. -->
  
== Research topics ==
+
==Research topics==
* structure-based drug design
+
*structure-based drug design
* high-resolution protein crystallography
+
*high-resolution protein crystallography
  
== References ==
+
==MSGPP==
 +
I am part of the Medical Structural Genomics of Pathogenic Protozoa Consortium (MSGPP). The pathogenic protozoa we study include the following:
 +
===[[wikipedia:Trypanosoma|Trypanosoma]]===
 +
;''[[wikipedia:Trypanosoma cruzi|Trypanosoma cruzi]]'' : Chagas' Disease
 +
;''[[wikipedia:Trypanosoma brucei|Trypanosoma brucei]]'' : Sleeping Sickness
 +
;''[[wikipedia:Leishmania|Leishmania spp.]]'' : Leishmaniasis
 +
===[[wikipedia:Apicomplexa|Apicomplexa]]===
 +
;''[[wikipedia:Plasmodium falciparum|Plasmodium falciparum]]'' : Malaria
 +
;''[[wikipedia:Plasmodium vivax|Plasmodium vivax]]'' : Malaria
 +
;''[[wikipedia:Toxoplasma gondii|Toxoplasma gondii]]'' : Toxoplasmosis
 +
===Others===
 +
;''[[wikipedia:Entamoeba histolytica|Entamoeba histolytica]]'' : Amoebiasis
 +
;''[[wikipedia:Giardia lamblia|Giardia lamblia]]'' : Giardiasis
 +
;''[[wikipedia:Cryptosporidium parvum|Cryptosporidium parvum]]'' : Cryptosporidiosis
 +
 
 +
==References==
 
<references/>
 
<references/>
=== Further reading ===
+
===Further reading===
* Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and ''E. coli'' heat-labile enterotoxin. ''JACS, 124:8818-8824''.
+
*Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and ''E. coli'' heat-labile enterotoxin. ''JACS, 124:8818-8824''.
* Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. ''Current Opinion in Structural Biology, 10:680-686''.
+
*Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. ''Current Opinion in Structural Biology, 10:680-686''.
* Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. ''Acta Cryst, D55:1997-2004''.
+
*Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. ''Acta Cryst, D55:1997-2004''.
* Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. ''Acta Cryst, D55:1109-1117''.
+
*Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. ''Acta Cryst, D55:1109-1117''.
  
 
==See also==
 
==See also==
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*[[Python Macromolecular Library]] (mmLib)
 
*[[Python Macromolecular Library]] (mmLib)
  
== External links ==
+
==External links==
* [http://www.bmsc.washington.edu/people/merritt/ Dr. Ethan A. Merritt Laboratory website]
+
*[http://www.bmsc.washington.edu/people/merritt/ Dr. Ethan A. Merritt Laboratory website]
* [http://skuld.bmsc.washington.edu/~tlsmd/ TLSMD Server]
+
*[http://skuld.bmsc.washington.edu/~tlsmd/ TLSMD Server]
* [http://www.sgpp.org/ Structural Genomics of Pathogenic Protozoa]
+
*[http://www.sgpp.org/ Structural Genomics of Pathogenic Protozoa]
  
 
[[Category:Academic Research]]
 
[[Category:Academic Research]]

Revision as of 01:02, 1 August 2007

The Dr. Ethan A. Merritt Laboratory

Research topics

  • structure-based drug design
  • high-resolution protein crystallography

MSGPP

I am part of the Medical Structural Genomics of Pathogenic Protozoa Consortium (MSGPP). The pathogenic protozoa we study include the following:

Trypanosoma

Trypanosoma cruzi 
Chagas' Disease
Trypanosoma brucei 
Sleeping Sickness
Leishmania spp. 
Leishmaniasis

Apicomplexa

Plasmodium falciparum 
Malaria
Plasmodium vivax 
Malaria
Toxoplasma gondii 
Toxoplasmosis

Others

Entamoeba histolytica 
Amoebiasis
Giardia lamblia 
Giardiasis
Cryptosporidium parvum 
Cryptosporidiosis

References

Further reading

  • Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin. JACS, 124:8818-8824.
  • Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. Current Opinion in Structural Biology, 10:680-686.
  • Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. Acta Cryst, D55:1997-2004.
  • Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. Acta Cryst, D55:1109-1117.

See also

External links