Difference between revisions of "Dr. Ethan A. Merritt Laboratory"
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| − | The '''Dr. Ethan A. Merritt Laboratory''' | + | The '''Dr. Ethan A. Merritt Laboratory''' is where I did [[:Category:Academic Research|scientific research]], scientific programming, and worked as a Linux System Administrator from October 2006 to October 2010. |
| − | == Research topics == | + | ==Research topics== |
| − | * structure-based drug design | + | *[[TLSMD]] (Translation, Libration, Screw Molecular Dynamics) |
| − | * high-resolution protein crystallography | + | *structure-based drug design |
| + | *high-resolution protein crystallography | ||
| − | == References == | + | ==Peer-reviewed papers published== |
| + | * Frank Zucker, '''P. Christoph Champ''', and Ethan A. Merritt (2010). "[https://docs.google.com/viewer?a=v&pid=explorer&chrome=true&srcid=0B7cFvC52gEb9MTRmNDQyNmYtZDVhNS00OTViLTkxZGItODk3ZmU2ZjdjYzM5&hl=en Validation of crystallographic models containing TLS or other descriptions of anisotropy]". ''Acta Cryst., D66:889-900''. | ||
| + | |||
| + | ==MSGPP== | ||
| + | I was part of the Medical Structural Genomics of Pathogenic Protozoa Consortium (MSGPP). The pathogenic protozoa we studied included the following: | ||
| + | ===[[wikipedia:Trypanosoma|Trypanosoma]]=== | ||
| + | ;''[[wikipedia:Trypanosoma cruzi|Trypanosoma cruzi]]'' : Chagas' Disease (aka American Trypanosomiasis) | ||
| + | ;''[[wikipedia:Trypanosoma brucei|Trypanosoma brucei]]'' : Sleeping Sickness (aka African Trypanosomiasis) | ||
| + | ;''[[wikipedia:Leishmania|Leishmania spp.]]'' : Leishmaniasis | ||
| + | ===[[wikipedia:Apicomplexa|Apicomplexa]]=== | ||
| + | ;''[[wikipedia:Plasmodium falciparum|Plasmodium falciparum]]'' : Malaria | ||
| + | ;''[[wikipedia:Plasmodium vivax|Plasmodium vivax]]'' : Malaria | ||
| + | ;''[[wikipedia:Toxoplasma gondii|Toxoplasma gondii]]'' : Toxoplasmosis | ||
| + | ===Others=== | ||
| + | ;''[[wikipedia:Entamoeba histolytica|Entamoeba histolytica]]'' : Amoebiasis | ||
| + | ;''[[wikipedia:Giardia lamblia|Giardia lamblia]]'' : Giardiasis | ||
| + | ;''[[wikipedia:Cryptosporidium parvum|Cryptosporidium parvum]]'' : Cryptosporidiosis | ||
| + | |||
| + | ==References== | ||
<references/> | <references/> | ||
| − | === Further reading === | + | ===Further reading=== |
| − | * Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and ''E. coli'' heat-labile enterotoxin. ''JACS, 124:8818-8824''. | + | *Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and ''E. coli'' heat-labile enterotoxin. ''JACS, 124:8818-8824''. |
| − | * Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. ''Current Opinion in Structural Biology, 10:680-686''. | + | *Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. ''Current Opinion in Structural Biology, 10:680-686''. |
| − | * Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. ''Acta Cryst, D55:1997-2004''. | + | *Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. ''Acta Cryst, D55:1997-2004''. |
| − | * Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. ''Acta Cryst, D55:1109-1117''. | + | *Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. ''Acta Cryst, D55:1109-1117''. |
==See also== | ==See also== | ||
*[[TLSMD]] | *[[TLSMD]] | ||
*[[Python Macromolecular Library]] (mmLib) | *[[Python Macromolecular Library]] (mmLib) | ||
| + | *''[[Curriculum Vitae]]'' | ||
| − | == External links == | + | ==External links== |
| − | * [http://www.bmsc.washington.edu/people/merritt/ Dr. Ethan A. Merritt Laboratory website] | + | *[http://www.bmsc.washington.edu/people/merritt/ Dr. Ethan A. Merritt Laboratory website] |
| − | * [http://skuld.bmsc.washington.edu/~tlsmd/ TLSMD Server] | + | *[http://skuld.bmsc.washington.edu/~tlsmd/ TLSMD Server] |
| − | * [http://www. | + | *[http://www.msgpp.org/ Medical Structural Genomics of Pathogenic Protozoa] |
| + | ===Genome projects=== | ||
| + | *[http://www.plasmodb.org/ PlasmoDB] — ''Plasmodium'' spp. | ||
| + | *[http://www.genedb.org/ GeneDB] — ''Trypanosomatids, Entamoeba, Plasmodium'' | ||
| + | *[http://tcruzidb.org/ TcruziDB] — ''T. cruzi'' | ||
| + | *[http://cryptodb.org/ CryptoDB] — ''Cryptosporidium'' | ||
| + | *[http://gmod.mbl.edu/perl/site/giardia GardiaDB] — ''Giardia lamblia'' | ||
| + | *[http://www.toxodb.org/ ToxoDB] — ''Toxoplasma gondii'' | ||
[[Category:Academic Research]] | [[Category:Academic Research]] | ||
Latest revision as of 03:36, 27 December 2012
The Dr. Ethan A. Merritt Laboratory is where I did scientific research, scientific programming, and worked as a Linux System Administrator from October 2006 to October 2010.
Contents
Research topics
- TLSMD (Translation, Libration, Screw Molecular Dynamics)
- structure-based drug design
- high-resolution protein crystallography
Peer-reviewed papers published
- Frank Zucker, P. Christoph Champ, and Ethan A. Merritt (2010). "Validation of crystallographic models containing TLS or other descriptions of anisotropy". Acta Cryst., D66:889-900.
MSGPP
I was part of the Medical Structural Genomics of Pathogenic Protozoa Consortium (MSGPP). The pathogenic protozoa we studied included the following:
Trypanosoma
- Trypanosoma cruzi
- Chagas' Disease (aka American Trypanosomiasis)
- Trypanosoma brucei
- Sleeping Sickness (aka African Trypanosomiasis)
- Leishmania spp.
- Leishmaniasis
Apicomplexa
- Plasmodium falciparum
- Malaria
- Plasmodium vivax
- Malaria
- Toxoplasma gondii
- Toxoplasmosis
Others
- Entamoeba histolytica
- Amoebiasis
- Giardia lamblia
- Giardiasis
- Cryptosporidium parvum
- Cryptosporidiosis
References
Further reading
- Merritt EA, Zhang Z, Pickens JC, Ahn M, Hol WGJ, Fan E (2002). Characterization and crystal structure of a high-affinity pentavalent receptor-binding inhibitor for cholera toxin and E. coli heat-labile enterotoxin. JACS, 124:8818-8824.
- Fan E, Merritt EA, Verlinde CLMJ, Hol WGJ (2000). AB5 toxins: structures and inhibitor design. Current Opinion in Structural Biology, 10:680-686.
- Merritt EA (1999). Comparing anisotropic displacement parameters in protein structures. Acta Cryst, D55:1997-2004.
- Merritt EA (1999). Expanding the model: anisotropic displacement parameters in protein structure refinement. Acta Cryst, D55:1109-1117.
See also
External links
- Dr. Ethan A. Merritt Laboratory website
- TLSMD Server
- Medical Structural Genomics of Pathogenic Protozoa
